Matthew Mottola | What AI Can't Replace
"I'm going to say for full-time employees that spend over a billion on talent, I'm saying there's going to be 40% layoffs. And they might say only 10%, but in reality, they're recalibrating easily up to 40%."
Latest Episode
185 - Medicine Without Permission | Niklas Anzinger
5 June 2026
Self-Sovereign Medicine: Biotech, Right to Try, and the Cracks in the FDA's Monopoly
– Niklas Anzinger is a German entrepreneur who has probably done more than any single person to put Próspera on the longevity biotech map. He is the founder and General Partner of Infinita VC, the first VC fund based in Próspera, Honduras, and the founder and CEO of Infinita City, formerly known as Vitalia, a network of hubs for longevity biotech acceleration. He also hosts the Stranded Technologies podcast, which has featured guests including Naval Ravikant and Balaji Srinivasan. Niklas is a returning guest to the show.
Timothy Allen sits down with Niklas in Austin, Texas, a few days after spending a month living alongside him in Próspera, for a wide-ranging conversation that moves from aging as a disease and the FDA's 1962 turning point, through China's rise to 30% of global pharma licensing deals in just ten years, Sid Sijbrandij's AI-assisted cancer fight and the Australian who built a personalised cancer vaccine for his dog using AlphaFold for roughly the cost of a genome sequence, to the Right to Try movement taking shape in Montana and New Hampshire and the regulatory model that could replace the FDA monopoly, and finally to what comes next for Próspera, phase one trials as a commercial beachhead, the Massimo Mazzone profit-first model at Ciudad Morazán, and why the ZEDE framework may be the most underappreciated governance innovation of our time.
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Tomek Kołodziejczuk | The Bitcoin Free City
"I came to visit, just to visit. On the second day, I bought a motorbike from Facebook Marketplace just to lock in. Okay, this might be my place."
Lucy Connolly | Jailed for a Tweet
"The minute you don't agree with something they do, they'll come for you too. Don't for one minute think that you're safe. So why are you supporting this? Because it could happen to any one of you."
Paloma Lecheta | Brazil's First Free City
"If you're ruthless about figuring it out, people will support you. And it's a matter of execution, right? So are we going to be the crazy or are we going to be the visionaries? It all comes down to executing and getting it done... and it being okay if it fails."
Crémieux | Why Bad Ideas Persist
"Every country is run poorly, in my opinion. I don't think any country is run very well. Even Singapore is not run very well. They're too restrictive there."
Liam Bates | Make Sealand Great Again
"We've lived this life. My dad has. And my grandfather before him. We're sure of where we want to take it. It's not just dreams. It's grounded in reality. We've got a plan of how to get there. Now we just need to go and do it."
Patri Friedman | 8 Hard Truths from 25 Years of Investing in Free Cities
"There's so much LARPing... It's when you imitate the superficialities of something without actually doing it. The thing is that starting a new country is so fun and so romantic and so exciting and so unbelievably hard that even if you seriously try to do it, you're going to naturally find that it's so much easier t...
Gabriel Delgado | The Próspera Master Plan
"The most important thing that can happen now with this new government for every other project out there.. is for Próspera to be successful. Because the more successful we are, the more people can point to us and say we're going to replicate that in our country."
James Price | Why Everything Feels Broken
“When Starmer came in in 2024, how many people across the entire British state changed jobs? Two hundred... One hundred ministers… and one hundred special advisors… And that’s it. And everybody else in that deep state stayed exactly the same.”
Oswald Horowitz | The Last Free Place
"The film is not necessarily a sad story about someone dying. It's about someone that had this dream that they believed in more than life itself, quite literally. He was quite happy to die for this dream, for what might have happened."
Patrik Schumacher | The Architecture of Spontaneous Order
"Land use should not be prescribed by any planning regime. People come together into a city by seeking out very particular connections. And they have to find each other. There needs to be the degree of freedom to associate and self-organize what I call the co-location synergies."
Mailyn Salabarria | The Hidden Path to Tyranny
"You can vote your way into socialism, but you can only shoot your way out. They're never going to leave power."
Joe Quirk | The Ultimate Exit Strategy
"The golden age of voluntarism, anarcho-capitalism has already emerged. It's all over two-thirds of the Earth's surface. It's completely flourishing. It's long since entered its golden age. We've already proved that it works because it emerged naturally on the sea. It's called the cruise ship industry."
Lotta Moberg | The Truth About Special Economic Zones
"There were probably a lot of brown envelopes on the table involved - they said, okay, have this zone then."
Tim Stern | Leaving Europe Is The Rational Choice
"I want to be back in my tribe. I want to have strong people which I can rely on, which I can do business with, which I know, which have my back and I have theirs.. And if we are building this place right now, why would I fill it with people I don't know and I don't give a shit about?"
Mitchell Suchner | The First Operational Seasteading Resort
"If I can sell someone something to buy, they might buy it. If you can sell someone something that they can live in, they're likely to buy it. If you can sell someone something that they can live in and also generates passive income for them, they're very likely to buy it."
Vikram Bharati | At the Intersection of Free Cities & Network States
"The free cities community seems very much more buttoned up and more pragmatic - real estate, free cities, development, SEZs. You need lawyers, you need bankers. And then the network state community, there's a lot more dreamers, young dreamers who want to do pop-up cities. But there's a convergence in betwee...
Mikkel Thorup | The Global Freedom Map Is Changing
"How do you get out of this? How do you separate yourself from your government today? How do you protect your wealth and your ability to provide for your family today?"
Christoph Heuermann: You Can Live Tax Free Almost Anywhere
“Why do you need Free Cities if you can live tax-free everywhere?”
Rahim Taghizadegan: Exit Is More Powerful Than Voice
“Politics is overrated, generally.”
Mason: The Last Piece in the Puzzle for the Sovereign Individual
“We didn’t design a boat. We designed an apartment and made it float.”